52 articles - From Friday Oct 10 2025 to Friday Oct 17 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Inflamm Bowel Dis |
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| Prevalence and Associated Factors of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease: An Updated Global Systematic Review and Meta-Analysis of over 1.5 Million Individuals.
NAFLD is a common comorbidity among patients with IBD, affecting over one in four individuals, with higher prevalence observed in adults, males, and certain geographic regions. Variation by diagnostic modality and disease location was also noted; however, these subgroup findings are based on limited data and should be interpreted with caution. Overall, the results highlight the importance of incorporating liver health screening into routine IBD management, particularly for high-risk populations, and underscore the need for future prospective studies to refine risk stratification and management strategies. |
| J Crohns Colitis |
| Glucagon-Like Peptide 1 Receptor Agonists (GLP1-RA) and the Clinical Outcomes of Inflammatory Bowel Disease (IBD): A Systematic Review and Meta-analysis.
Interpretation Patients with IBD and obesity using GLP1-RAs were able to achieve significant weight loss and had lower risks of surgery and hospitalizations. Our findings require confirmation in prospective trials of GLP1-RAs in IBD. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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| Associations between domestic water hardness and the risk of experiencing fifteen different cardiovascular events: A prospective cohort study of 324,136 UK Biobank participants.
Methods This cohort study included UK Biobank participants whose address codes were used to obtain DWH data (calcium carbonate [CaCO and Ca were associated with lower CVD risk. Combined DWH was associated with increased chronic rheumatic heart disease risk. |
| Optimizing glycemic variability in type 2 diabetes using simple dietary and culinary recommendations to modulate starch digestibility: a randomized controlled trial.
Modulating starch digestibility represents an effective and accessible strategy for enhancing GV and thus glycemic management in T2D, allowing patients with suboptimal glycemic control to reach recommended glycemic targets. (identifier NCT03847701; registered on February 18, 2019) |
| Prenatal and preschool micronutrient supplementation and behavioral outcomes in school aged children in Nepal - a cohort study.
Our study shows potential benefit of early life exposure to micronutrient supplementation for child related behavior outcomes in a South Asian setting where inadequate diets and nutrition deficiencies exist. |
| Preoperative plasma short- and branched-chain fatty acids in relation to risk of complications after colorectal cancer surgery: a prospective cohort study.
Our findings suggest that microbial fermentation processes, mainly those resulting in higher SCFA levels, may be linked to postoperative recovery. These findings provide leads for future studies investigating the role of preoperative diet, especially the balance between fiber and protein intake, and microbial metabolism in relation to postoperative recovery of patients with CRC. Clinical trial details This study was registered at clinicaltrials.gov with registration number NCT03191110. |
| Inflamm Bowel Dis |
| Comparative Risk of Serious Infections Associated With Treatment of Inflammatory Bowel Disease.
In this nationwide IBD cohort, there was not an increased risk of infection-related hospitalization among patients exposed to vedolizumab, ustekinumab, and tofacitinib as compared with patients on anti-TNF inhibitor and TP combination therapy and rates of infection-related hospitalization were low overall. These findings should guide clinical decision making and patient-physician discussions when selecting a therapeutic agent with the primary emphasis on efficacy. |
| Incidence of Ocular Manifestation After Adult-Onset Inflammatory Bowel Disease: A 20-Year Population-Based Cohort Study.
OMs in adult-onset IBD are infrequent but clinically relevant, particularly among CD patients and those with markers of severe disease. Clinician awareness and early referral remain essential for prompt diagnosis and management. |
| Introduction to the IBD Journal Supplement: "Prevention of IBD: Forecasting and Forestalling Inflammatory Bowel Disease Onset".
While landmark initiatives across the globe are currently paving the way for biomarker validation and trial implementation, harmonizing terminology and defining preclinical stages are essential next steps. Ultimately, understanding disease initiation may enable transformative strategies, shifting the paradigm from treatment to true prevention and potentially altering the course of IBD. |
| J Crohns Colitis |
| Development and validation of a novel patient-reported outcome for microscopic colitis-Microscopic Colitis Score (MCS).
MCSQ and MCS are valid, reliable, and responsive tools that meet FDA and EMA standards. Both accurately reflect the diverse symptoms of MC. Compared to the binary Hjortswang criteria, MCS provides a nuanced evaluation of disease activity and holds promise for assessing therapeutic efficacy in future trials. |
| How Long is Long Enough? Timing of Pre-conceptional Remission Predicts Relapse Risk During Pregnancy in IBD.
This large multicenter study demonstrates that disease activity within 6 months before conception significantly increases the risk of relapse during pregnancy in women with inflammatory bowel disease. Our study is the first to assess both the pre-conceptional disease course and a broad set of known risk factors in a real-world cohort. |
| Spatial transcriptomics and immunophenotyping uncover chronic inflammation-induced immune adaptations favoring dysplasia development in patients at risk of colitis-associated cancer.
Chronic inflammation induces endogenous mechanisms to protect from inflammation-induced damage, including increased anti-inflammatory cytokine production and decreased levels of CD8+ IELs. While this may limit inflammation, these mechanisms may also reduce immunosurveillance, favoring the development of CAC. |
| Spatial transcriptomics reveals unique inflammatory signatures across all anatomic locations in post-operative crohn's disease.
Application of spatial transcriptomics revealed a common disease signature for post-operative CD across the colon, neo-terminal ileum, and anastomosis. Inflamed biopsies from al locations demonstrated similar immune cell and inflammatory gene expression patterns as opposed to hypoxic pathways, and unique inflammatory pathways were revealed. |
| Switching to subcutaneous administration may offer more profound remission compared to intensified intravenous therapy in patients with inflammatory bowel disease and partial response following induction with intravenous vedolizumab: the PRIVEDO study.
In IBD patients with partial response to IV VDZ induction, switching to SC VDZ may lead to more profound remission than continuing IV optimization. |
| Liver Transpl |
| Analysis of the impact of female sex and muscle mass on serum creatinine and waitlist priority for liver transplantation.
Serum creatinine and MELD scores are likely to be underestimated due to reduced muscle mass rather than female sex in cirrhotic patients on the liver transplantation waitlist. |
| Anonymous living donation expands access and enhances equity in pediatric liver transplantation: A retrospective cohort study.
Integrating anonymous non-directed donors enlarges the living-donor pool, decreases time to transplantation for vulnerable children, and preserves the superior long-term outcomes achieved with living-donor organs. Embedding A-LDLT alongside DDLT can reduce disparities and enable timely, life-saving transplantation for children without directed donors while maintaining the advantages associated with living-donor grafts. |
| Long-term outcome of the initial cases with recipient-side minimal invasive liver transplantation: Single-center comparison study.
TLLT in adult is feasible and safe, achieving outcomes equivalent to open recipient surgery despite longer ischemic and operative times. Careful patient selection and technical refinements-potentially augmented by robotic assistance-may further optimize minimal invasive surgery for the recipient. |
| Optimizing liver transplant outcomes for colorectal liver metastases in the united states.
Given the potential variability of oncologic selection criteria and graft quality, we call for the standardization of nationally accepted selection criteria for listing patients for LT with uCRLM and for providing early access with high-quality organs. To achieve this it is imperative to create, or update and maintain national databases that allow for the collection of more granular oncological variables. |
| Organ monitoring and identification of ischemic liver injury during ex situ porcine liver machine perfusion - a randomized controlled study.
Measurements taken in the hilar plate show the ability to identify bile duct damage while not introducing measurement devices to the vulnerable bile duct itself. Our findings enable more objective and timely selection of transplantable livers and warrant further investigation in clinical studies. |
| Safety and feasibility of duct-to-duct biliary anastomosis in pediatric liver transplantation: A single-center retrospective study.
Appropriate learning and decision-making processes ensure the safety and feasibility of DDA, with excellent perioperative and long-term outcomes. It is therefore recommended that DDA should be considered the first choice for biliary reconstruction in eligible pediatric transplant patients. |
| Safety of immunotherapy post liver transplantation- A multicentered study of a prospective standardized clinical practice protocol.
ICI treatment in the immunosuppressed LTr is feasible with careful immunosuppression management and follow-up. Demonstrating a low rejection risk should allow for earlier utilization of these agents to improve cancer prognosis. Optimizing rejection risk with cancer response requires ongoing study. |
| Variations in liver allocation systems across continents with a focus on MELD exceptions.
Additionally, the adoption of living donation and donation after circulatory death (DCD) is discussed. The study involves contributions from a diverse group of world experts in liver transplantation and may serve as an essential resource to foster international dialogue as countries strive to optimize organ allocation policy, including MELD exceptions. |
| Pancreas |
| Genome-wide Association Analysis for Organ Failure in Acute Pancreatitis.
We performed a GWAS examining organ failure in AP and identified 9 candidate loci, which did not pass the genome-wide significance threshold. Three candidate genes, CHD9, FYB and MMADHC, were identified through eQTL and differential gene expression analyses. These may represent novel therapeutic targets for organ failure in AP. |
| Immune Checkpoint Inhibitor-Induced Pancreatic Injury: An Emerging Form of Immune-Mediated Pancreatitis.
ICI-PI is an uncommon yet clinically important entity that shows a distinct clinicopathologic profile from other forms of AIP. Clear diagnostic criteria, practical treatment pathways, and prospective registries are needed to guide therapy, inform rechallenge decisions, and define long-term outcomes. |
| Outcomes of Early Enteral Feeding (<48 hours) in Patients with Predicted Severe Acute Pancreatitis.
This novel study demonstrated that initiating EEN within 48 hours in predicted SAP patients significantly improves outcomes, highlighting its importance in management. These findings support EEN as a clinical standard for SAP patients and call for future prospective studies to confirm its benefits. |
| Participant Retention in a Prospective Multicenter Cohort of Participants With Pancreatitis and Factors Associated With Attrition.
Integrating medical records review substantially enhanced retention rates, enabling robust analyses of pancreatitis outcomes and disease progression. Older age and better self-reported physical health were key predictors of retention, highlighting the need for targeted strategies to enhance engagement among younger participants and those with poorer health in long-term studies. |
| Pancreatology |
| Aiming for high quality of care for completed resections and improved margin status in pancreatic cancer surgery.
Timely progression to primary treatment had the most significant association with achieving complete resection status. |
| Effects of Krüppel-like factor 4 mutation on the clinicopathological characteristics and its related protein expressions in intraductal papillary mucinous neoplasm of the pancreas.
KLF4 mutations might enhance p21 expression, possibly influencing the indolent characteristics of non-invasive IPMNs and providing a new biomarker strategy for risk stratification in patients with IPMNs. |
| Efficacy of diagnosing intraductal papillary mucinous neoplasm with mural nodules by contrast-enhanced endoscopic ultrasound using time-intensity curve analysis with a new support program: A multicenter retrospective study (with video).
The contrast ratio calculated using TIC analysis with the support program is potentially useful for differentiating between IPMNs with LGD and those with HGD/IC. |
| Low-dose aspirin use is associated with reduced 30- and 90-day mortality and overall improved outcomes in patients with acute pancreatitis: A multinational multicenter analysis.
Low-dose ASA was associated with lower mortality, fewer complications, and lower recurrence in patients with AP, as compared to patients without ASA use at 30- and 90-days. These findings may suggest that ASA's anti-inflammatory and antiplatelet properties could potentially mitigate the inflammatory cascade in AP pathophysiology. Further studies are warranted to explore the direct impact of ASA on AP. |
| Modified TNM staging system for well-differentiated pancreatic neuroendocrine tumors: A comparative study with the AJCC 9th edition.
The proposed mTNM staging system was superior to the current AJCC 9th system for well-differentiated p-NETs. |
| Pancreatic cancer burden across Southeast Asia from 1990 to 2021: An analysis of incidence and mortality based on the global burden of disease study 2021.
The substantial rise in pancreatic cancer burden across Southeast Asia highlights the need for improved healthcare infrastructure, especially in lower-SDI countries. Regional collaboration and targeted interventions focusing on early detection, treatment access, and modifiable risk factors are crucial to reducing pancreatic cancer mortality. Strengthening healthcare systems and public health initiatives will be vital to address this growing regional and global health challenge. |
| The distance to arteries predicts the oncological outcome in pancreatic cancer surgery - results from a 3D reconstruction model.
Measurement of the distance to the closest artery in preoperative imaging has strong prognostic value for recurrence and overall survival in patients with resectable PDAC. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Clin Nutr |
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| Beyond serum phosphorus: metabolic balance studies offer insight on effects of phosphate binders in dialysis patients. |
| Has the golden egg lost its luster? |
| Inflamm Bowel Dis |
| How Should an IBD Prevention Trial Be Designed?
Prevention trials in IBD hold promise but require careful design informed by experiences from other IMIDs. Central to this effort are the development of validated predictive tools, ethically appropriate interventions, and international collaboration to assemble well-powered at-risk cohorts. |
| IBD Prediction Is Possible, but How Far Are We from Implementing It?
This review emphasizes the importance of continued longitudinal studies and clinical trials to validate predictive models. Ultimately, the integration of early risk prediction holds the potential to reduce IBD incidence through targeted, proactive strategies. |
| Intervention(s) in the Early-Life Period to Modulate Inflammatory Bowel Disease Risk: What Could Be the Impact?
Emerging research areas include maternal dietary interventions, microbiome-based therapies, and the utilization of digital tools for risk monitoring. This review also addresses ethical and implementation challenges inherent to early-life prevention research and intervention. |
| Response to Letter to the Editor regarding "The Correlation between Fecal Amino Acids, Colonic Mucosal Taste Receptors, and Clinical Features and Indicators of Ulcerative Colitis: A Multicenter Exploratory Study". |
| Towards IBD Prediction and Prevention: The Contribution of Genetics and Genomics.
The review interrogates the risk for IBD and highlights some opportunities that may lead to the future possibility of preventing IBD. If strategies for prevention, early detection, early intervention, or even avoidance are to be developed, the obvious genetic underpinnings of IBD cannot be ignored. |
| Pancreatology |
| Cracking the code to early detection of pancreatic cancer using AI. |
| Textbook oncologic outcome in pancreatic cancer surgery: Quality metric or prognostic marker? |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Liver Transpl |
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| Cervical cancer screening remains low in liver transplant patients regardless of demographics: A single-center review. |
| Postoperative complications after liver transplantation: Are we making progress? |
| Reframing hepatitis B prophylaxis in liver transplant recipients - time to focus on cure. |
| The hemostatic cascade by viscoelastic testing in liver transplantation: Refining targets for possibly refined intervention. |
| Pancreas |
| Pancreatic Steatosis is an Impractical Biomarker for Predicting Outcomes in Acute Pancreatitis. |
| Pancreatology |
| A model to predict participant retention in longitudinal acute pancreatitis studies. |
| Risk of acute and chronic pancreatitis in patients with psoriasis: A Danish nationwide cohort study. |
Letters to the editors and authors’ replies
| Pancreatology |
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| Microbiome-genetic interplay in intraductal papillary mucinous neoplasms: A critical appraisal of emerging evidence. |
| Response to the letter to the editor: "Refining the prognostic utility of CA19-9 in neoadjuvant therapy for pancreatic cancer: Emphasizing serial monitoring and subgroup differentiation". |
| TSH as a biomarker for recurrent hypertriglyceridemia pancreatitis: Key questions on thresholds, diet, and model generalization. |